A recent review of epidemiologic literature found consistently reduced cancer and heart disease rates in persons with high compared with low whole-grain intakes.
We hypothesized that whole-grain intake was associated with a reduced risk of ischemic heart disease (IHD) death.
We studied 34492 postmenopausal women aged 55-69 y and free of IHD at baseline in 1986.
There were 438 IHD deaths between baseline and 1995.
Usual dietary intake was determined with use of a 127-item food-frequency questionnaire.
Whole-grain intake in median servings/d was 0.2,0.9,1.2,1.9, and 3.2 for quintiles of intake.
The unadjusted rate of IHD death was 2.0/1 x 103 person-years in quintile I and was 1.7,1.2,1.0, and 1.4 IHD deaths/1 x 103 person-years in succeeding quintiles (P for trend<0.001).
Adjusted for demographic, physiologic. behavioral, and dietary variables, relative hazards were 1.0. 0.96. 0.71,0.64, and 0.70 in ascending quintiles (P for trend=0.02).
The lower risk with higher whole-grain intake was not explained by intake of fiber or several other constituents of whole grains.
A clear inverse association between whole-grain intake and risk of IHD death existed.
A causal association is plausible because whole-grain foods contain many phytochemicals, including fiber and antioxidants, that may reduce chronic disease risk.
Whole-grain intake should be studied further for its potential to prevent IHD and cancer.
Mots-clés Pascal : Farine complète, Consommation alimentaire, Fibre alimentaire, Antioxydant, Epidémiologie, Ischémie, Myocarde, Prévention, Alimentation, Origine végétale, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Cardiopathie coronaire, Myocarde pathologie, Homme, Femelle, Iowa, Etats Unis, Amérique du Nord, Amérique, Postménopause
Mots-clés Pascal anglais : Wholemeal, Food intake, Dietary fiber, Antioxidant, Epidemiology, Ischemia, Myocardium, Prevention, Feeding, Plant origin, Cardiovascular disease, Vascular disease, Coronary heart disease, Myocardial disease, Human, Female, Iowa, United States, North America, America, Postmenopause
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0415265
Code Inist : 002B30A02A. Création : 25/01/1999.