Data from a previous study of the cytogenetic effects, in cultured lymphocytes, of exposure to the atomic bomb in Hiroshima have been reanalyzed to determine the relationship between the occurrence of « rogue » cells in an individual and the frequency of « simple » chromosomal damage in the nonrogue cells of the same individual.
Rogue cells are cells with complex chromosomal damage, currently believed to be a manifestation of the activity of a human polyoma virus termed « JC. » Among a total of 1,835 persons examined, there were 45 exhibiting rogue cells.
A total of 179,599 cells were scored for simple chromosomal damage.
In both the exposed and the control populations, there was an absolute increase of 1.5% in the frequency of simple chromosomal damage in the nonrogue cells of those exhibiting rogue cells, when compared with the frequencies observed in those not exhibiting rogue cells, which is a statistically significant difference.
It is argued that this phenomenon, occurring not only in lymphocytes but possibly also in other cells/tissues, may play a contributory role in the origin of malignancies characterized by clonal chromosome abnormalities.
Unexpectedly, among those exhibiting rogue cells, there was a disproportionately greater representation of persons who had received relatively high radiation exposures from the bomb. (...)
Mots-clés Pascal : Virus JC, Polyomavirus, Papovaviridae, Virus, Homme, Lymphocyte, Japon, Asie, Défaut complexe, Chromosome, Prévalence, Charge atomique, Exposition, Chromosome anormal, Aberration chromosomique, Irradiation(personne), Virose, Infection, Cellule, Cytogénétique, Biologie moléculaire
Mots-clés Pascal anglais : JC virus, Polyomavirus, Papovaviridae, Virus, Human, Lymphocyte, Japan, Asia, Complex defect, Chromosome, Prevalence, Atomic charge, Exposure, Abnormal chromosome, Chromosomal aberration, Radiation exposure(person), Viral disease, Infection, Cell, Cytogenetics, Molecular biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0410273
Code Inist : 002B23A. Création : 25/01/1999.