Patients with acromegaly have a reduced life expectancy, with the accepted causes for premature death being vascular and respiratory disease.
Increased mortality from malignant disease has also been reported.
We, therefore, performed a multicenter retrospective cohort study of 1362 patients with acromegaly and investigated the relationships of mortality and cancer incidence with GH levels, duration of disease, and age at diagnosis.
The overall cancer incidence rate [standardized incidence ratio, 0.76 ; 95% confidence interval (CI), 0.60-0.95] was lower than that in the general population of the United Kingdom, and there was no significant increase in site-specific cancer incidence rates.
The overall cancer mortality rate was not increased, but the colon cancer mor (standardized mortality ratio, 2.47 ; 95% CI, 1.31-4.22) was higher than expected.
Mortality rates due to colon cancer, all malignant disease, cardiovascular disease and overall mortality were increased with higher posttreatment GH levels (P for trends,<0.02,<0.05,<0.02, and<0.0001).
The overall mortality rate in patients with acromegaly with posttreatment GH levels less than 2.5 ng/mL 5 mU/L) was comparable to that in the general population of the United Kingdom (standardized mortality ratio, 1.10 ; 95% CI, 0.89-1.35). (...)
Mots-clés Pascal : Acromégalie, Epidémiologie, Tumeur maligne, Incidence, Mortalité, Etude comparative, STH, Exploration hormonale, Plasma sanguin, Durée, Age, Royaume Uni, Europe, Homme, Endocrinopathie, Hypophyse pathologie, Système ostéoarticulaire pathologie, Hormone adénohypophysaire, Hormone protéine
Mots-clés Pascal anglais : Acromegaly, Epidemiology, Malignant tumor, Incidence, Mortality, Comparative study, STH, Hormonal investigation, Blood plasma, Duration, Age, United Kingdom, Europe, Human, Endocrinopathy, Pituitary diseases, Diseases of the osteoarticular system, Adenohypophyseal hormone, Protein hormone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0410171
Code Inist : 002B30A01A2. Création : 25/01/1999.