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  1. An economic evaluation of hepatitis A vaccination in Dutch military personnel.

    Article - En anglais

    We analyzed the cost-effectiveness of hepatitis A vaccination regimens using a mathematical simulation model.

    Passive immunization and two active vaccination strategies (with and without prior screening) were compared with « doing nothing. » Hepatitis A antibodies were determined in 2,325 Dutch marines ; other input data were retrieved from published and unpublished sources.

    The prevalence of hepatitis A antibody was 14%. Screening before vaccination was identified as appropriate at a prevalence>20%. Passive immunization was the cheapest prevention for a single 6-month deployment per 10 years.

    The inactivated vaccine containing 1,440 enzyme-linked immunosorbent assay units without prior screening was identified as the best option for more frequent deployments.

    It was cost-saving with two or more missions per 10 years.

    A 5.3% hepatitis A attack rate validated the investment for this policy.

    Overall, immunization with inactivated hepatitis A vaccine without prior screening proved to be the optimum strategy for troops at regular risk.

    Mots-clés Pascal : Hépatite virale A, Virose, Infection, Vaccin, Dépistage, Immunoprophylaxie, Personnel, Militaire, Néerlandais, Analyse coût efficacité, Homme, Appareil digestif pathologie, Foie pathologie, Vaccination, Organisation santé, Prévention

    Mots-clés Pascal anglais : Viral hepatitis A, Viral disease, Infection, Vaccine, Medical screening, Immunoprophylaxis, Personnel, Military, Dutch, Cost efficiency analysis, Human, Digestive diseases, Hepatic disease, Vaccination, Public health organization, Prevention

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0409324

    Code Inist : 002B05A02. Création : 25/01/1999.