We studied the seroprevalence and transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8), among 215 Ugandan children, adolescents and young adults.
We measured antibodies to a latent nuclear antigen (LANA) and a lytic cycle protein encoded by open reading frame (orf) 65.
Infection with KSHV/HHV8 occurred during early childhood and reached adult levels (approx. 50%) before the age of puberty.
In children younger than 12 years of age, antibodies to LANA and the orf65 protein were independently associated with hepatitis B infection (p<0.005).
KSHV/HHV8 infection was not associated with antibodies to hepatitis A virus and hepatitis C virus, nor with the quality of the water supply, household size, previous blood transfusions, number of boylgirl friends or marital status.
Antibodies to the orf65 protein, but not LANA, were weakly associated with a history of i.v. injections.
Our results show that, in contrast to its sexual mode of transmission among homolbisexual men and sexually transmitted diseases clinic attendees of Northern Europe and the US, transmission of KSHV in Uganda occurs largely before puberty.
Among Ugandan children, KSHV transmission follows a horizontal pattern similar to other herpesviruses, in particular the related gamma herpesvirus, EpsteinBarr virus.
Transmission of KSHV may be facilitated by living conditions that also promote infection with hepatitis B virus.
Mots-clés Pascal : Virose, Infection, Sérologie, Prévalence, Epidémiologie, Facteur risque, Hépatite virale, Approvisionnement eau, Maladie sexuellement transmissible, Transfusion, Sang, Injection, Voie intraveineuse, Ouganda, Afrique, Enfant, Homme, Adolescent, Adulte jeune, Appareil digestif pathologie, Foie pathologie, Herpesvirus hominis 8
Mots-clés Pascal anglais : Viral disease, Infection, Serology, Prevalence, Epidemiology, Risk factor, Viral hepatitis, Water supply, Sexually transmitted disease, Transfusion, Blood, Injection, Intravenous administration, Uganda, Africa, Child, Human, Adolescent, Young adult, Digestive diseases, Hepatic disease, Herpesvirus hominis 8
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0407551
Code Inist : 002B05C02B. Création : 25/01/1999.