Transmission of human immunodeficiency virus (HIV) and mortality was studied among infants of infected women in Zimbabwe.
Of 367 infants born to HIV-infected women, 72 (19.6%) died compared with 20 (5.4%) of 372 infants of uninfected women (P<. 01).
Infection by HIV DNA polymerase chain reaction among infants who survived>7 days and died within 2 years could be assessed in 87% (58/67) of infants of infected women and 83% (516) of infants of uninfected women ; transmission occurred in 40 of 58 infants.
Among 27 infected infants tested at birth, 19 (70%), 5 (19%), and 3 (11%) were apparently infected via in utero, intrapartum or early postpartum, and late postpartum transmission, respectively.
The majority of HIV-infected infants who died in the first 2 years of life were likely to have acquired in utero infection.
Mots-clés Pascal : Virus HIV1, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Nourrisson, Homme, Transmission mère enfant, Epidémiologie, Etude longitudinale, Mortalité, Séropositivité, SIDA, Virose, Infection, Zimbabwe, Afrique, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : HIV-1 virus, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Infant, Human, Mother to child transmission, Epidemiology, Follow up study, Mortality, Seropositivity, AIDS, Viral disease, Infection, Zimbabwe, Africa, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0406807
Code Inist : 002B05C02D. Création : 25/01/1999.