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  1. Randomised controlled trial of brief neonatal exposure to cows'milk on the development of atopy.

    Article - En anglais

    Objective

    To determine the effect of brief early exposure to cows'milk on atopy in the first 2 years of life.

    Design-Double blind, placebo controlled, randomised feeding intervention trial (Bokaal study).

    Setting-Dutch midwifery practices

    Participants-1533 breast fed neonates.

    Intervention-Exposure to cows'milk protein (n=758) or a protein free placebo (n=775) during the first 3 days of life.

    Main outcome measures-Clinical atopic disease and any positive radioallergosorbent (RAST) tests at 1 year of age.

    Results

    Atopic disease in the first year was found in 10.0% (cows'milk) v 9.3% (placebo) of the children, with a relative risk of 1.07 ; in the second year, atopic disease was found in 9.6% v 10.2%, respectively, with a relative risk of 0.94.

    Per protocol analysis showed similar results

    Any RAST positive test was found in 9.4% (cows'milk) v 7.9% (placebo) of children, with a relative risk of 1.19.

    Stratified analysis for high family risk of allergy showed a doubled incidence of atopic disease but no effect from the intervention.

    Conclusion-Early and brief exposure to cows'milk in breast fed children does not increase the risk of atopic disease in the first 2 years.

    Mots-clés Pascal : Atopie, Allaitement, Lait vache, Exposition, Néonatal, Epidémiologie, Facteur risque, Nourrisson, Homme, Enfant, Etude en condition contrôlée, Randomisation, Pays Bas, Europe, Immunopathologie, Allergie

    Mots-clés Pascal anglais : Atopy, Breast feeding, Cow milk, Exposure, Neonatal, Epidemiology, Risk factor, Infant, Human, Child, Controlled environment study, Randomization, Netherlands, Europe, Immunopathology, Allergy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0406359

    Code Inist : 002B06C01. Création : 25/01/1999.