Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses.
Background Few meta-analyses of randomised trials assess the quality of the studies included.
Yet there is increasing evidence that trial quality can affect estimates of intervention efficacy.
We investigated whether different methods of quality assessment provide different estimates of intervention efficacy evaluated in randomised controlled trials (RCTs).
Methods We randomly selected 11 meta-analyses that involved 127 RCTs on the efficacy of interventions used for circulatory and digestive diseases, mental health, and pregnancy and childbirth.
We replicated all the meta-analyses using published data from the primary studies.
The quality of reporting of all 127 clinical trials was assessed by means of component and scale approaches.
To explore the effects of quality on the quantitative results, we examined the effects of different methods of incorporating quality scores (sensitivity analysis and quality weights) on the results of the meta-analyses.
Findings The quality of trials was low.
Masked assessments provided significantly higher scores than unmasked assessments (mean 2.74 [SD 1.10] vs 2.55 [1.20]). Low-quality trials (score<2), compared with high-quality trials (score>2), were associated with an increased estimate of benefit of 34% (ratio of odds ratios [ROR] 0.66 [95% Cl 0.52-0.83]). Trials that used inadequate allocation concealment, compared with those that used adequate methods, were also associated with an increased estimate of benefit (37% ; ROR=0.63 [0. (...)
Mots-clés Pascal : Métaanalyse, Essai clinique, Randomisation, Evaluation performance, Homme, Echelle mesure
Mots-clés Pascal anglais : Metaanalysis, Clinical trial, Randomization, Performance evaluation, Human, Measurement scale
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0405770
Code Inist : 002B30A11. Création : 25/01/1999.