The objective of the study was to determine the human teratogenic risk of vitamin A supplementation during pregnancy.
Paired analysis of cases with congenital abnormalities and matched healthy controls was performed in the large population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994.
Of 35 727 pregnant women who had control infants without defects, 3399 (9.5%) were treated with vitamin A. Of 20830 pregnant women who had case offspring with congenital abnormalities, 1642 (7.9%) were treated with vitamin A, a rate that is significantly lower than that of the control group (p<0.001).
The case-control pair analysis also showed a lower rate of vitamin A treatment during pregnancy and in the first trimester of gestation in most congenital abnormality groups.
Thus, use of low or moderate doses of vitamin A (<10,000 IU) during the first trimester of pregnancy (i.e., organogenesis) is not teratogenic but presents some protective effect to the fetus.
Mots-clés Pascal : Prévention, Maladie congénitale, Nourrisson, Homme, Régime alimentaire enrichi, Rétinol, Evaluation, Risque, Tératogène, Alimentation, Vitamine, Femelle, Hongrie, Europe, Gestation
Mots-clés Pascal anglais : Prevention, Congenital disease, Infant, Human, Supplemented diet, Retinol, Evaluation, Risk, Teratogen, Feeding, Vitamin, Female, Hungary, Europe, Pregnancy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0405722
Code Inist : 002B30A03B. Création : 25/01/1999.