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  1. Superficial vein thrombosis of lower limbs : influence of factor V Leiden, factor II G20210A and overweight.

    Article - En anglais

    Superficial vein thrombosis (SVT) has been reported in patients with thrombophilia.

    In the presen unmatched case-control study.

    The two most common thrombophilic abnormalities (factor V Leiden and factor II G20210A) were searched for in 112 consecutive patients with SVT of lower limbs and in 180 healthy donors.

    FV Leiden was present in 16/112 (14.3%) SVT patients and I 1/180 (6.1%) controls (odds ratio 2.51,95% Cl 1.04-6.24) and FII G20210A in 4/112 (3.6%) patients and 2/180 (1.1%) controls (OR 3.28,95% CI 0.46-36.84).

    In addition, body mass index (BMI) = 28 kg/m2was also associated with SVT (OR 2.81,95% CI 1.60-5.00).

    After adjustement for BMI =28 kg/m2, the association between FV Leiden and SVT remained strong though no longer statistically significant.

    Among patients with SVT, the presence of FV Leiden was independently associated with the absence of varicose veins (OR 4.62. 95% CI 1.25-18.0) and with a BMI =28 kg/m2 (OR 3.74,95% Cl 1.05-15.1), In conclusion. both FV Leiden and overweight seem to predispose to SVT. a finding that should be confirmed in larger studies.

    Mots-clés Pascal : Thrombose, Veine superficielle, Membre inférieur, Facteur V Leiden, Résistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Prothrombine, Facteur coagulation, Variabilité génétique, Surcharge pondérale, Prévalence, Epidémiologie, Suisse, Europe, Etude cas témoin, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie, Hémopathie, Coagulopathie, Maladie héréditaire

    Mots-clés Pascal anglais : Thrombosis, Superficial vein, Lower limb, Factor V Leiden, Resistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Prothrombin, Coagulation factor, Genetic variability, Overweight, Prevalence, Epidemiology, Switzerland, Europe, Case control study, Human, Cardiovascular disease, Vascular disease, Venous disease, Hemopathy, Coagulopathy, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0405704

    Code Inist : 002B12B03. Création : 25/01/1999.