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  1. Incidence of cataract operations in Finnish male smokers unaffected by a tocopherol or bêta carotene supplements.

    Article - En anglais

    Objective

    To examine the effect of a tocopherol and bêta carotene supplementation on the incidence of age related cataract extraction.

    Setting-The Alpha-tocopherol Betacarotene (ATBC) Study was a randomised, double blind, placebo controlled, 2x2 factorial trial conducted in south western Finland.

    The cataract surgery study population of 28 934 male smokers 50-69 years of age at the start.

    Intervention-Random assignment to one of four regimens : alpha tocopherol 50 mg per day, carotene 20 mg per day, both alpha tocopherol and bêta carotene, or placebo.

    Follow up continued for five to eight years (median 5.7 years) with a total of 159 199 person years.

    Outcome measure-Cataract extraction, ascertained from the National Hospital Discharge Registry.

    Results

    425 men had cataract surgery because of senile or presenile cataract during the follow up.

    Of these, 112 men were in the alpha tocopherol alone group, 112 men in the bêta carotene alone group, 96 men in the alpha tocopherol and carotene group, and 105 men in the placebo group.

    When supplementation with alpha tocopherol and with carotene were introduced to a Cox proportional hazards model with baseline characteristics (age, education, history of diabetes, body mass index, alcohol consumption, number of cigarettes smoked daily, smoking duration, visual acuity, and total cholesterol), neither alpha tocopherol (relative risk, RR, 0.91,95% confidence intervals, CI, 0.74,1.11) nor carotene (RR 0.97,95% CI 0.79,1. (...)

    Mots-clés Pascal : Cataracte, Tabagisme, Supplémentation, Tocophérol, Carotène, Chirurgie, Epidémiologie, Activité biologique, Incidence, Homme, Finlande, Europe, Essai thérapeutique contrôlé, Randomisation, Oeil pathologie, Cristallin pathologie, Segment antérieur pathologie

    Mots-clés Pascal anglais : Cataract, Tobacco smoking, Supplementation, Tocopherol, Carotene, Surgery, Epidemiology, Biological activity, Incidence, Human, Finland, Europe, Controlled therapeutic trial, Randomization, Eye disease, Lens disease, Anterior segment disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0405689

    Code Inist : 002B09G. Création : 25/01/1999.