Low frequency of recent parvovirus infection in a population-based cohort of patients with early inflammatory polyarthritis.
To determine the contribution of human parvovirus B19 infection in explaining the incidence of early inflammatory polyarthritis (IP) in a population.
Setting-The Norfolk Arthritis Register (NOAR) is a community-based programme aiming to ascertain all new cases of IP arising in a population that lead to attendance at primary care.
Subjects-147 newly ascertained subjects with IP with a disease duration of less than 16 weeks.
Methods-Full clinical appraisal of all subjects who were followed up for three years.
B19 IgM assayed with a third generation antibody capture enzyme immunoassay.
Only four (2.7%) patients had evidence of recent B19 infection, only one of whom did not satisfy criteria for rheumatoid arthritis (RA).
Conclusion-B19 infection does not explain more than a small proportion of either RA or undifferentiated IP cases occurring in the population.
Mots-clés Pascal : Polyarthrite rhumatoïde, Pathogénie, Homme, Polyarthrite inflammatoire, Infection, Virus B19, Erythrovirus, Parvovirinae, Parvoviridae, Virus, Virose, Exploration, Méthode immunoenzymatique, Epidémiologie, Incidence, Immunoglobuline, IgM, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Milieu urbain
Mots-clés Pascal anglais : Rheumatoid arthritis, Pathogenesis, Human, Inflammatory polyarthritis, Infection, Virus B19, Erythrovirus, Parvovirinae, Parvoviridae, Virus, Viral disease, Exploration, Enzyme immunoassay, Epidemiology, Incidence, Immunoglobulins, IgM, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Urban environment
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0405313
Code Inist : 002B15D. Création : 25/01/1999.