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  1. Ossification of the posterior longitudinal ligament in three geographically and genetically different populations of ankylosing spondylitis and other spondyloarthropathies.

    Article - En anglais

    Study design-Cross sectional

    Research questions- (a) Is any clinical variable of ankylosing spondylitis (AS) associated with the presence of ossification of the posterior longitudinal ligament (OPLL) ? and (b) Is OPLL present in patients with AS from different geographical or genetic backgrounds ?

    Methods-Three groups were assembled 

    (1) a prospective group of 103 consecutive AS patients from two community based rheumatology clinics from Guadalajara, who were evaluated using :

    • a questionnaire with disease characteristic variables ;

    • clinical assessment by a neurologist ;

    • lateral radiographic views of the cervical spine and somatosensory evoked potentials (SSEP). (2) Fifty one spondyloarthropathies (SpA) patients from Mexico city whose cervical spine films were retrospectively reviewed. (3) Thirty nine AS patients from Edmonton,

    • Canada whose cervical spine films were retrospectively reviewed and compared with 72 controls.


    Group 1 : 74% of the 103 patients were men and 86% were HLA-B27 positive.

    The mean age was 35 years, and mean (SD) disease duration 10 (8) years.

    OPLL was reported in 16 patients (15.5% ; 95% C I 9,22).

    OPLL was statistically associated with older age (p=0.001), longer disease duration (p=0.001), clinical myelopathy (p=0.03), worst functional index (p=0.042), restricted axial movement measurements (all p<0.001), radiological sacroiliitis (p<0.001 for linear association), osteitis pubis (p=0.009), hip involvement (p=0. (...)

    Mots-clés Pascal : Spondylarthrite ankylosante, Pathogénie, Homme, Spondylarthropathie, Symptomatologie, Ethnie, Ossification, Ligament longitudinal postérieur, Environnement, Epidémiologie, Prévalence, Déterminisme génétique, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Muscle strié pathologie, Milieu urbain

    Mots-clés Pascal anglais : Ankylosing spondylitis, Pathogenesis, Human, Spondylarthropathy, Symptomatology, Ethnic group, Ossification, Posterior longitudinal ligament, Environment, Epidemiology, Prevalence, Genetic determinism, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Striated muscle disease, Urban environment

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0405309

    Code Inist : 002B15D. Création : 25/01/1999.