Follow-up of occupational asthma after removal from or diminution of exposure to the responsible agent : Relevance of the length of the interval from cessation of exposure.
We set the hypothesis that follow-up surveys of occupational asthma (OA) could now show better improvement in the asthmatic condition because of a more prolonged interval since removal from exposure than in previously reported studies.
Ninety-nine subjects with OA were assessed and were separated into two groups according to the duration of cessation of exposure : (1) group removed for =5 years : 48 subjects studied 8.9±2.2 years after cessation of exposure ; (2) group removed for<5 years : 51 subjects with OA, comparable in terms of history and functional results at time of diagnosis, with a time lapse from last exposure of 3.1±1.2 years.
On the follow-up visit, questionnaires including information on the current and previous use of inhaled steroids, spirometry, and methacholine tests were administered and results were compared with those obtained at the time of diagnosis.
At the follow-up visit, no significant changes in spirometry were observed in the two
However, a significant improvement in provocative concentration of methacholine causing a 20% fall in FEV1 (PC20) from a mean value of 1.5 to 3.7 mg/mL was documented (p<0.001).
The proportion of subjects having normal PC20 at the follow-up visit was significantly higher in the group removed from exposure for>5 years than in the group removed for<5 years (16/33 vs 8/42 ; p=0.01). (...)
Mots-clés Pascal : Asthme, Maladie professionnelle, Arrêt exposition, Agent, Responsabilité, Spirométrie, Pronostic, Homme, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Médecine travail
Mots-clés Pascal anglais : Asthma, Occupational disease, Exposure stopping, Agent, Responsibility, Spirometry, Prognosis, Human, Respiratory disease, Obstructive pulmonary disease, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0404920
Code Inist : 002B11B. Création : 25/01/1999.