The significance of specific IgG4 antibodies to methyltetrahydrophthalic anhydride in occupationally exposed subjects.
Background A definitive role for allergen-specific IgG4 as either an anaphylactic or a blocking antibody, or both, remains controversial.
Objective A population of 148 workers from two condenser plants (A and B) using epoxy resin with methyltetrahydrophthalic anhydride (MTHPA) was studied to evaluate the significance of MTHPA-specific IgG4 antibody.
Methods The workers were evaluated through questionnaire and serological investigations.
Results Ninety-seven (66%) of the currently exposed workers had positive MTHPA-specific IgE.
IgE-sensitized workers in each plant had significantly more eye and nose complaints than unsensitized workers (P<0.03).
As the result of multiple logistic analysis, specific IgE antibodies was the most important predictor of work-related symptoms and its effect was greater than that of specific IgG4 (odds ratio 16.7 and 3.68, respectively).
These indicate an IgE-mediated mechanism in most cases of work-related symptoms associated with MTHPA exposure.
However, it cannot be denied that specific IgG4 is an anaphylactic antibody.
Furthermore, IgE-sensitized workers in these plants displayed work-related symptoms despite the presence of specific IgG4.
The frequency of positive specific IgG4 in continuously exposed workers was significantly (P<0.02) higher in plant A than in plant B, reflecting the difference of the MTHPA levels between the two plants.
In plant A, the frequency of positive specific IgG4 was significantly (P<0. (...)
Mots-clés Pascal : IgG4, Anticorps, Spécificité, Exposition professionnelle, Epoxyde résine, Homme, Allergie, ORL pathologie, Oeil pathologie, Appareil respiratoire pathologie, IgE, Exploration immunologique, Allergène, Médecine travail, Immunopathologie, Méthyltétrahydrophtalique anhydride
Mots-clés Pascal anglais : IgG4, Antibody, Specificity, Occupational exposure, Epoxy resin, Human, Allergy, ENT disease, Eye disease, Respiratory disease, IgE, Immunological investigation, Allergen, Occupational medicine, Immunopathology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0404365
Code Inist : 002B06C02. Création : 25/01/1999.