A geographic cluster of 10 cases of pulmonary hemorrhage and hemosiderosis in infants occurred in Cleveland, Ohio, between January 1993 and December 1994.
This community-based case-control study tested the hypothesis that the 10 infants with pulmonary hemorrhage and hemosiderosis were more likely to live in homes where Stachybotrys atra was present than were 30 age-and ZIP code-matched control infants.
We investigated the infants'home environments using bio-aerosol sampling methods, with specific attention to S atra.
Air and surface samples were collected from the room where the infant was reported to have spent the most time.
Mean colony counts for all fungi averaged 29 227 colony-forming units (CFU)/m3 in homes of patients and 707 CFU/m3 in homes of controls.
The mean concentration of S atra in the air was 43 CFU/m3 in homes of patients and 4 CFU/m3 in homes of controls.
Viable S atra was detected in filter cassette samples of the air in the homes of 5 of 9 patients and 4 of 27 controls.
The matched odds ratio for a change of 10 units in the mean concentration of S atra in the air was 9.83 (95% confidence interval, 1.08-3 X 106).
The mean concentration of S atra on surfaces was 20 X 106 CFU/g and 0.007 X 106CFU/g in homes of patients and controls, respectively.
Infants with pulmonary hemorrhage and hemosiderosis were more likely than controls to live in homes with toxigenic S atra and other fungi in the indoor air.
Mots-clés Pascal : Hémorragie, Poumon, Aigu, Hémosidérose, Etiopathogénie, Exposition, Mycose, Infection, Stachybotrys, Fungi Imperfecti, Fungi, Thallophyta, Effet environnement, Statut social, Etude comparative, Enfant, Homme, Pigment, Appareil respiratoire pathologie, Poumon pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Métabolisme pathologie
Mots-clés Pascal anglais : Hemorrhage, Lung, Acute, Hemosiderosis, Etiopathogenesis, Exposure, Mycosis, Infection, Stachybotrys, Fungi Imperfecti, Fungi, Thallophyta, Environmental effect, Social status, Comparative study, Child, Human, Pigments, Respiratory disease, Lung disease, Cardiovascular disease, Vascular disease, Metabolic diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0404310
Code Inist : 002B11D. Création : 25/01/1999.