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  1. Prevalence of hepatitis G virus RNA and anti-E2 in a Japanese haemodialysis population.

    Article - En anglais

    Background

    Patients on maintenance haemodialysis (HD) are at greater risk of parenterally transmitted infection with not only A-E hepatitis virus but also with hepatitis G virus (HGV) that has been recovered from patients with non A-E hepatitis.

    The prevalence of HGV infection in HD patients, which is based on the detection of HGV RNA using reverse transcription-polymerase chain reaction techniques, differs widely between countries.

    Recently, a new assay has been developed that detects an antibody to the envelope protein (E2) of HGV (anti-E2) that appears to be associated with the loss of HGV RNA from the serum and which may be a useful marker for previous HGV infection.

    Methods

    To determine the actual prevalence of HGV infection in maintenance HD patients, we examined both HGV RNA and anti-E2 antibody in sera from 200 patients undergoing maintenance HD.

    Results

    Thirty patients (15%) tested positive for HGV RNA, and 14 (7%) tested positive for E2 antibody.

    Of these, two individuals tested positive for both markers.

    Overall, 21% of these HD patients had been exposed to HGV.

    A logistic regression analysis failed to show any clinical feature associated with the detection of HGV RNA.

    The duration of HD and the presence of HCV RNA were associated with anti-E2.

    Male gender and HCV RNA were risk factors for the elevation of serum ALT activities.

    HGV RNA sequences of the patients were not identical to each other. (...)

    Mots-clés Pascal : Insuffisance rénale, Chronique, Hémodialyse, Séropositivité, Traitement, Complication, Prévalence, Homme, Japonais, Appareil urinaire pathologie, Rein pathologie, Epuration extrarénale, Virus hépatite G

    Mots-clés Pascal anglais : Renal failure, Chronic, Hemodialysis, Seropositivity, Treatment, Complication, Prevalence, Human, Japanese, Urinary system disease, Kidney disease, Extrarenal dialysis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0403358

    Code Inist : 002B27B03. Création : 25/01/1999.