Patients on maintenance haemodialysis (HD) are at greater risk of parenterally transmitted infection with not only A-E hepatitis virus but also with hepatitis G virus (HGV) that has been recovered from patients with non A-E hepatitis.
The prevalence of HGV infection in HD patients, which is based on the detection of HGV RNA using reverse transcription-polymerase chain reaction techniques, differs widely between countries.
Recently, a new assay has been developed that detects an antibody to the envelope protein (E2) of HGV (anti-E2) that appears to be associated with the loss of HGV RNA from the serum and which may be a useful marker for previous HGV infection.
To determine the actual prevalence of HGV infection in maintenance HD patients, we examined both HGV RNA and anti-E2 antibody in sera from 200 patients undergoing maintenance HD.
Thirty patients (15%) tested positive for HGV RNA, and 14 (7%) tested positive for E2 antibody.
Of these, two individuals tested positive for both markers.
Overall, 21% of these HD patients had been exposed to HGV.
A logistic regression analysis failed to show any clinical feature associated with the detection of HGV RNA.
The duration of HD and the presence of HCV RNA were associated with anti-E2.
Male gender and HCV RNA were risk factors for the elevation of serum ALT activities.
HGV RNA sequences of the patients were not identical to each other. (...)
Mots-clés Pascal : Insuffisance rénale, Chronique, Hémodialyse, Séropositivité, Traitement, Complication, Prévalence, Homme, Japonais, Appareil urinaire pathologie, Rein pathologie, Epuration extrarénale, Virus hépatite G
Mots-clés Pascal anglais : Renal failure, Chronic, Hemodialysis, Seropositivity, Treatment, Complication, Prevalence, Human, Japanese, Urinary system disease, Kidney disease, Extrarenal dialysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0403358
Code Inist : 002B27B03. Création : 25/01/1999.