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  1. A randomized controlled trial of the effect of pertussis vaccines on atopic disease.

    Article - En anglais


    Pertussis vaccination in infancy has been suggested to increase the risk for development of asthma and allergy.


    To assess sensitization rates and development of atopic diseases in a prospective randomized controlled trial of pertussis vaccine.

    Patlents and Methods 

    A total of 669 children were randomized to 1 of 4 vaccine groups (2-component acellular pertussis, 5-component acellular pertussis, whole-cell pertussis vaccines, and placebo [diphtheria and tetanus toxoids]). Diphtheria and tetanus toxoids were also given to the children in the pertussis vaccine groups.

    The children were evaluated by means of questionnaires at age 2 months, 7 months, and 21/2 years ; skin prick tests at age 7 months and 21/2 years ; and blinded clinical investigation at age 2'/2 years.

    The families were contacted at regular intervals to assess possible adverse effects after the vaccinations and symptoms of whooping cough.


    The cumulative incidence of atopic diseases was 30% and incidence rates were similar in the 4 groups after adjusting for family history.

    Exposure to environmental tobacco smoke and home dampness did not confound these results.

    The frequency of adverse effects did not differ appreciably between atopic and nonatopic children, with the exception that a nodule at the vaccination site was more frequent after whole-cell pertussis vaccination in the nonatopic children. (...)

    Mots-clés Pascal : Vaccination, Coqueluche, Bactériose, Infection, Effet biologique, Incidence, Allergie, Asthme, Atopie, Essai clinique, Randomisation, Enfant, Homme, Immunologie, Appareil respiratoire pathologie, Immunopathologie, Bronchopneumopathie obstructive

    Mots-clés Pascal anglais : Vaccination, Whooping cough, Bacteriosis, Infection, Biological effect, Incidence, Allergy, Asthma, Atopy, Clinical trial, Randomization, Child, Human, Immunology, Respiratory disease, Immunopathology, Obstructive pulmonary disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0403258

    Code Inist : 002B05A02. Création : 25/01/1999.

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