Objective To assess the detection and control of risk factors for atherosclerosis in patients with SLE who subsequently develop acute coronary events.
Methods Patients followed at the University of Toronto Lupus Clinic who developed a myocardial infarction (MI) or acute coronary insufficiency (ACI) and who had 2 years of follow-up prior to their event were identified and their case notes reviewed.
The management of potentially reversible risk factors in this cohort was assessed.
Results Twenty-four patients (18 female, 6 male) were studied.
The mean age at the coronary event was 50 years and the mean duration of SLE was 13.5 years.
Nineteen patients had MI and 5 had ACI.
Risk factors identified were hypertension (16), obesity/Cushing's (19), smoking (16), hypercholesterolaemia (11), steroid use (22), hyperglycaemia (4) and cardiac involvement with SLE (4).
In the two years prior to the event, hypertension and cardiac involvement were appropriately managed in almost all cases.
Sixty percent had attempts made to reduce or stop their steroid therapy.
Two of four cases with hyperglycaemia and 5 of 11 patients with hypercholesterolaemia had no appropriate action noted.
No smoking advice was recorded, while one obese patient had weight reduction advice recorded.
Conclusion SLE patients who develop coronary events have potentially reversible risk factors prior to the event. (...)
Mots-clés Pascal : Lupus érythémateux, Disséminé, Complication, Athérosclérose, Artère coronaire, Facteur risque, Cardiopathie coronaire, Aigu, Homme, Epidémiologie, Traitement, Prévention, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Myocarde pathologie
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Complication, Atherosclerosis, Coronary artery, Risk factor, Coronary heart disease, Acute, Human, Epidemiology, Treatment, Prevention, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Cardiovascular disease, Vascular disease, Myocardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0403089
Code Inist : 002B07. Création : 25/01/1999.