Screening digital rectal examination and prostate cancer mortality : A population-based case-control study.
Although digital rectal examination (DRE) for the detection of prostate cancer has been recommended by many professional groups and has become part of the general physical examination, no randomized clinical trial has demonstrated the efficacy or effectiveness of this practice.
We conducted a population-based case-control study to evaluate the association between DRE and prostate cancer mortality.
With the resources of the Rochester Epidemiology Project, all 173 men who died of prostate cancer in Olmsted County from 1976 to 1991, who were resident at the time of diagnosis, were identified.
For each case, two control patients were drawn from the population, matched for residence at the time of diagnosis in the case, birth date, and duration of medical record in Olmsted County.
Trained nurse ors reviewed the community medical records for up to 10 years before the date of diagnosis in the case for mention of DRE and specific findings associated with each mention.
Case subjects were less likely than control subjects to have had any DRE in the 10 years before diagnosis (matched odds ratio [OR]=0.51 ; 95% confidence interval [Cl]=0.31,0.84).
When limited to DREs without mention of signs or symptoms that might raise suspicion of prostate cancer, the association was even stronger (OR=0.31 ; 95% Cl=0.19,0.49).
Adjustment for educational attainment, marital status, and comorbid conditions did little to alter the associations. (...)
Mots-clés Pascal : Tumeur maligne, Prostate, Mâle, Homme, Dépistage, Toucher rectal, Corrélation, Mortalité, Etude cas témoin, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie
Mots-clés Pascal anglais : Malignant tumor, Prostate, Male, Human, Medical screening, Rectal touch, Correlation, Mortality, Case control study, Male genital diseases, Urinary system disease, Prostate disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0398330
Code Inist : 002B14D02. Création : 25/01/1999.