Relation between the changes of oncogene versus tumor suppressor gene interaction and the transition of cancer risk from female dominance through no sex discrimination to male dominance, as investigated by the reciprocal regression analysis of 5 human neoplasias.
We have been investigating the mathematical nature of intercancer linkage that underlies the mutual regulation of cancer risks between any 2 tumors in their variations in time and space.
Applications of both sequential regression test and topological manipulation of age-adjusted incidence rate (AAIR) data set enabled us to prepare the oncogene (Onc) activation profile and the tumor suppressor gene (TSG) inactivation profile for each tumor.
The purpose of this study was to investigate the relation between the changes of 2 cancer gene profiles and the sex discrimination of cancer risk in 7 human neoplasias.
Results obtained are as follows :
I) The sex discrimination of cancer risk could better be defined by the use of log-transformed AAIR data rather than of untransformed AAIR data. ii) The sex discrimination of cancer risk, as calculated with the AAIR data of 47 population units of the world, is as follows : a) breast cancer (Br), M : F=1 : 120.2 ; b) thyroid cancer (Thy), M : F=1 : 2.64 ; c) colon cancer (Co), M : F=1.18 : 1 ; d) liver cancer (Li), M : F=2.63 : 1 ; e) lung cancer (Lu), M : F=3.66 : 1 ; f) esophageal cancer (Eso), M : F=3.68 : 1 ; g) laryngeal cancer (Lar), M : F=7.26 : 1. iii) Female-dominant cancers were associated with inversion (Br) or defectiveness (Thy) of male oncogene profile, whereas male-dominant cancers were associated with inversion (Lar) or defectiveness (Li, Lu and Eso) of female Onc profiles. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Thyroïde, Côlon, Oesophage, Larynx, Gène suppresseur tumeur, Gène onc cellulaire, Protooncogène, Sexe, Discrimination, Analyse régression, Facteur risque, Analyse statistique, Epidémiologie, Homme, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Thyroid gland, Colon, Esophagus, Larynx, Tumor suppressor gene, C-Onc gene, Protooncogene, Sex, Discrimination, Regression analysis, Risk factor, Statistical analysis, Epidemiology, Human, Mammary gland diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0397888
Code Inist : 002B04B. Création : 25/01/1999.