Esophageal impairment in adult celiac disease with steatorrhea.
A high prevalence of reflux esophagitis in celiac children and gut motor disorders in adult patients have been described.
The aim of this study is to investigate the prevalence of esophageal symptoms and the esophageal motility pattern in adult celiac patients before and after gluten-free diet.
In 22 consecutive adult celiac patients, before and after gluten-free diet, and in controls we calculated an esophageal symptom score regarding heartburn, regurgitation, dysphagia, and chest pain, and performed esophageal manometry using a constantly perfused multilumen catheter.
Patients were divided into two groups : with and without steatorrhea.
Before gluten-free diet, the prevalence of esophageal symptoms was 45.5% in all patients, but was significantly higher in patients with steatorrhea than in those without and in 44 control subjects (80% vs 16.7% and 27%, p<0.05).
Lower esophageal sphincter pressure was 17.5 ± 5.3 in all patients, but was significantly lower in patients with steatorrhea than in patients without steatorrhea and 11 controls subjects (13.1± 4.1 vs 21.0± 2.9 and 20.7 ± 3.7 mm Hg (mean ± SD, p<0.05).
After the diet, the prevalence of esophageal symptoms diminished in all patients (9% vs 45.4%, p<0.05) and lower esophageal sphincter pressure, measured in 13 patients, increased (19.0± 3.7 vs 15.7 ± 5.3 mm Hg, p<0.05). (...)
Mots-clés Pascal : Coeliaque maladie, Epidémiologie, Association, Stéatorrhée, Exploration clinique, Trouble fonctionnel, Oesophage, Relation, Traitement diététique, Prévalence, Homme, Italie, Europe, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Oesophage pathologie
Mots-clés Pascal anglais : Coeliac disease, Epidemiology, Association, Steatorrhea, Clinical investigation, Dysfunction, Esophagus, Relation, Diet therapy, Prevalence, Human, Italy, Europe, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology, Esophageal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0397264
Code Inist : 002B13B03. Création : 25/01/1999.