Objective To investigate the role of occupational exposures in the risk of developing urothelial cancer.
Materials and methods Occupational histories, obtained using a self-administered questionnaire, for 8 () 3 patients with urothelial cancer (first diagnosed 1991-93) were compared with similar information for 2135 matched controls.
Relative risks (RRs) were estimated using conditional logistic regression.
Comparisons were also made with historical regional employment information available from the 1971 census.
Results There were many statistically significant positive associations for urothelial cancer risks and ever being employed in specified occupations (with or without statistical adjustment for smoking status in 1991).
Smoking-adjusted RRs of>2.0 were obtained for seven occupations ; manufacture of fire lighters/patent fuels (RR 4.3 (). 95% confidence interval 0.78-23.79). rodent extermination (3.71,1.20-11.48), manufacture of dyestuffs (2.61. 0.98-7.00). leather work (2.51. 1.44-4.35), cable manufacturing industry (2.46,1.20-5.04). textile printing and dyeing (2.32. 0.98-5.45). and sewage works (2.19,1.16-4.11).
Analyses of the occupations followed in 1971 (thus allowing for 20-year latency) indicated an elevated RR for workers in the plastics industry (5.22. 1.57-17.36).
Conclusions The historical legacy of exposure to aromatic amines in the rubber, cable-making. dyestuffs and other industries remains. (...)
Mots-clés Pascal : Tumeur maligne, Voie urinaire, Homme, Exposition professionnelle, Etude cas témoin, Carcinogène, Epidémiologie, Maladie professionnelle, Royaume Uni, Europe, Amine, Produit chimique, Industrie transformation plastique, Industrie textile, Voie urinaire pathologie, Appareil urinaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Urinary tract, Human, Occupational exposure, Case control study, Carcinogen, Epidemiology, Occupational disease, United Kingdom, Europe, Amine, Chemical product, Plastics processing industry, Textile industry, Urinary tract disease, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0397179
Code Inist : 002B14D02. Création : 25/01/1999.