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  1. Limbal vernal keratoconjunctivitis in the tropics.

    Article - En anglais

    Objective 

    This study aimed to describe the pathology of vernal keratoconjunctivitis (VKC) in children from Kenya.

    Design 

    Case series.

    Participants 

    Ten patients with clinically active and untreated limbal VKC and five age-matched control subjects without external eye disease were recruited from a district eye hospital in Kenya.

    Main Outcome Measures 

    Paraffin sections of limbal and tarsal conjunctiva were examined by tinctorial and immunocytochemical methods to characterize the inflammatory infiltrate.

    Results 

    In comparison with control subjects, patients with VKC were more likely to show squamous metaplasia of the tarsal conjunctiva.

    The patients with VKC had cellular infiltration of both the stroma and epithelium consistent with chronic inflammation, particularly in the biopsy specimens taken from the limbus.

    In tarsal conjunctiva, the stromal infiltrate consisted of a diffuse T-lymphocyte reaction with clustering of B-lymphocytes ; mast cells, immunoglobulin E (IgE) plasma cells, and eosinophils also were prominent.

    Mast cells and eosinophils were found within the epithelium in the more severely inflamed biopsy specimens.

    Conclusions 

    These features are similar to those in reports of VKC in temperate regions, although the degree of B-lymphocyte clustering is greater in tropical patients with VKC.

    Although none of the patients had other symptoms of atopy, the authors findings are consistent with those for an allergic basis for this disease.

    Mots-clés Pascal : Conjonctivite printanière, Immunocytochimie, Exploration, Limbe sclérocornéen, Conjonctive, Kenya, Afrique, Epidémiologie, Enfant, Homme, Oeil pathologie, Conjonctive pathologie, Immunopathologie, Allergie, Anatomopathologie

    Mots-clés Pascal anglais : Vernal conjunctivitis, Immunocytochemistry, Exploration, Rim of sclera, Conjunctiva, Kenya, Africa, Epidemiology, Child, Human, Eye disease, Conjunctiva disease, Immunopathology, Allergy, Pathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0396329

    Code Inist : 002B06C05. Création : 25/01/1999.