Risk of inflammatory bowel disease attributable to smoking, oral contraception and breastfeeding in Italy : a nationwide case-control study.
Background Using data from a case-control study carried out in Italy 1989-1992, we estimated the odds ratios (OR) and the population attributable risks (AR) for inflammatory bowel diseases (IBD) in relation to smoking, oral contraception and breastfeeding in infancy.
Methods The study focused on 819 cases of IBD (594 ulcerative colitis : UC ; 225 Crohn's disease : CD) originating from populations resident in 10 Italian areas, and age-sex matched paired controls.
Results Compared with non-smokers, former smokers were at increased risk of UC (OR=3.0 ; 95% confidence interval [CI] : 2.1-4.3), whereas current smokers were at increased risk of CD (OR=1.7 ; 95% Cl : 1.1-2.6).
Females who reported use of oral contraceptives for at least one month before onset of symptoms had a higher risk of CD (OR=3.4 ; 95% CI : 1.0-11.9), whereas no significant risk was observed for UC.
Lack of breastfeeding was associated with an increased risk of UC (OR=1.5 ; 95% CI : 1.1-2.1) and CD (OR=1.9 ; 95% CI : 1.1-3.3).
Being a'former smoker'was the factor with the highest attributable risk of UC both in males (AR=28% ; 95% CI : 20-35%) and in females (AR=12% ; 95% Cl : 5-18%). Smoking was the factor with the highest attributable risk for CD in males (AR=31% ; 95% Cl : 11-50%). Lack of breastfeeding accounted for the highest proportion of CD in females (AR=11% ; 95% Cl : 1-22%). Oral contraceptive use accounted for 7% of cases of UC and for 11% of cases of CD. (...)
Mots-clés Pascal : Entérite Crohn, Rectocolite ulcérohémorragique, Tabagisme, Contraception, Voie orale, Allaitement, Etude cas témoin, Facteur risque, Homme, Epidémiologie, Italie, Europe, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire, Risque attribuable
Mots-clés Pascal anglais : Crohn disease, Ulcerative colitis, Tobacco smoking, Contraception, Oral administration, Breast feeding, Case control study, Risk factor, Human, Epidemiology, Italy, Europe, Digestive diseases, Intestinal disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0395662
Code Inist : 002B13B03. Création : 25/01/1999.