Stage of colon cancer at diagnosis : implications for risk factor associations ?
Background A potential source of bias in epidemiological studies comes from studying people at different stages of disease progression.
This can result in biased selection of cases or in errors of measurement of exposures.
Methods We use stage of disease at the time of diagnosis to evaluate how inclusion of people at different stages in the disease process can influence associations between environmental exposures and colon cancer.
Data used were generated from a large case-control study of colon cancer.
Results For most environmental exposures evaluated, including physical activity, body size, use of aspirin and of non-steroidal anti-inflammatory drugs, and dietary intake of folate and fibre, we did not observe differences in patterns of association by stage of disease at diagnosis.
However, for total energy and red meat intake (men only), alcohol consumption, cigarette smoking, and family history of colorectal cancer among first degree relatives, patterns of associations were stronger when colon cancer was detected at an earlier stage of disease progression than when it was detected at a more advanced stage.
Conclusions Most exposures did not differ by stage of disease, thus selectively excluding cases at different disease stages should not influence associations between these exposures and colon cancer. (...)
Mots-clés Pascal : Tumeur maligne, Côlon, Stade clinique, Epidémiologie, Facteur risque, Homme, Californie, Etats Unis, Amérique du Nord, Amérique, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Clinical stage, Epidemiology, Risk factor, Human, California, United States, North America, America, Digestive diseases, Intestinal disease, Colonic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0395588
Code Inist : 002B13B01. Création : 25/01/1999.