Background Mortality in specified clinical populations has often been regarded as a measure of treatment effectiveness.
This study examined time trends in mortality of drug addicts in the UK notified to the Home Office over a 27-year period.
Methods The study was a longitudinal analysis of routine mortality data of a population of newly notified addicts from 1967 to 1993.
Altogether, 92 802 addicts were newly notified during the study period, and they accounted for 687 673 person-years of observation.
The main outcome measures were age-specific all-causes mortality ; drug-related mortality : and age-and sex-specific standardized mortality ratios (SMR) 1967-1993.
Results There were significant differences in death rates between the periods 1967-1976 (19/1000 person-years) and 1984-1993 (10.5/1000 person-years).
Excess deaths were significantly higher among the 1967-1976 cohorts than in the 1984-1993 cohorts (SMR ratio=1.80,95% CI : 1.64-1.97).
The majority of deaths were drug-related, with those aged<45 years more likely to die of a drug-related cause than those older (OR=6.29,95% CI : 4.97-7.96).
Conclusions It appears that service provision has some impact on all-causes mortality among opiate addicts.
As services improved, there was a corresponding decline in mortality rates during the study period.
Further preventive measures, however, should be devised to reduce drug-related deaths.
Mots-clés Pascal : Toxicomanie, Mortalité, Epidémiologie, Evolution, Taux, Homme, Royaume Uni, Europe
Mots-clés Pascal anglais : Drug addiction, Mortality, Epidemiology, Evolution, Rate, Human, United Kingdom, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0395270
Code Inist : 002B18C05A. Création : 25/01/1999.