To assess the effects of folate intake and pregnancy on plasma total homocyst (e) ine concentrations in women during the second trimester of pregnancy compared with young, healthy nonpregnant women.
The diet provided either 450 or 850 mug of folate per day.
These levels are approximately the current (400 mug/day) and previous (800 mug/day) Recommended Dietary Allowances for folate in pregnant women.
Folate was provided as both food folate (120 mug/day) and supplemental folic acid (either 330 or 730 mug/day) for a period of 12 weeks.
Plasma homocyst (e) ine (sum of free and protein-bound homocysteine), serum folate, and erythrocyte folate concentrations were determined weekly.
Homocyst (e) ine concentrations were lower in pregnant women during the second trimester of normal pregnancy than in nonpregnant controls, independent of dietary folate intake.
The overall mean (± standard deviation) homocyst (e) ine concentration of the pregnant subjects (5.4 ± 1.4 mumol/L) was significantly lower than that observed in the nonpregnant control group (8.7 ± 1.7 mumol/L) (P<. 0001).
This difference in homocyst (e) ine concentrations remained constant throughout the 12 weeks of the investigation.
The folate intakes in this investigation were adequate to maintain constant homocyst (e) ine concentrations in pregnant and nonpregnant women. (...)
Mots-clés Pascal : Homocystéine, Plasma sanguin, Folate, Complément alimentaire, Gestation, Période activité génitale, Influence, Homme, Femelle
Mots-clés Pascal anglais : Blood plasma, Folate, Food supplement, Pregnancy, Sexually active period, Influence, Human, Female
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0395058
Code Inist : 002B30A01C. Création : 25/01/1999.