Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers.
Background Attention has long been drawn to the potentially harmful effects of coffee on health, however recent epidemiological studies have suggested unexpected, possibly beneficial effects of coffee against the occurrence of alcoholic liver cirrhosis and upon serum liver enzyme levels.
Methods We examined the potential inverse association between coffee drinking and serum concentrations of gamma-glutamyltransferase (GGT) and aminotransferases, with special reference to interaction with alcohol consumption, in a cross-sectional study involving 12 687 health examinees (7398 men and 5289 women) aged 40-69 years from over 1000 workplaces in Nagano prefecture in central Japan.
Those who had a history of liver disease and/or serum aminotransferases exceeding the normal range were excluded.
Possible confounding effects of alcohol consumption, body mass index, cigarette smoking, and green tea consumption were controlled through multivariate analyses.
Results Increased coffee consumption was strongly and independently associated with decreased GGT activity among males (P trend<0.0001) ; the inverse association between coffee and serum GGT was more evident among heavier alcohol consumers (P<0.0001), and was absent among non-alcohol drinkers.
Among females, however, coffee was only weakly related to lower GGT level. (...)
Mots-clés Pascal : Consommation alimentaire, Café, Consommation, Boisson alcoolisée, Transaminases, Transferases, Enzyme, Foie, Foie pathologie, Epidémiologie, Taux, Facteur risque, Homme, Mâle, Japon, Asie, Appareil digestif pathologie
Mots-clés Pascal anglais : Food intake, Coffee, Consumption, Alcoholic beverage, Transaminases, Transferases, Enzyme, Liver, Hepatic disease, Epidemiology, Rate, Risk factor, Human, Male, Japan, Asia, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0394907
Code Inist : 002B30A01A2. Création : 25/01/1999.