Doses and models in risk assessment analysis for bronchial hyperresponsiveness.
The aims of this study are :
(1) to evaluate whether the estimates of the association of risk factors with bronchial hyperresponsiveness (BHR) depends on the accumulated dose administered in challenge tests ; and (2) to verify whether a model developed for survival studies (Weibull regression) is suited to analyze methacholine dose-response curves.
For these purposes, 863 challenge tests, from EC Respiratory Health Survey in Italy, up to a cumulative dose of 6 mg methacholine, were analyzed by Weibull regression and by traditional methods (logistic model and linear model), both before and after truncation of the curves at 2 mg.
With all methods the main risk factors for BHR were respiratory symptoms and atopy while age and airway caliber exerted a protective action.
Our results confirmed that in epidemiological surveys 2 mg methacholine is enough to fully appreciate the effect of risk factors on BHR and showed that the Weibull model explains the observed variability better than linear and logistic regressions.
Mots-clés Pascal : Hyperréactivité, Poumon, Asthme, Chlorure de méthacholine, Test provocation, Relation dose réponse, Facteur risque, Survie, Modèle statistique, Epidémiologie, Homme, Poumon pathologie, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Régression Weibull
Mots-clés Pascal anglais : Hyperreactivity, Lung, Asthma, Methacholine chloride, Provocation test, Dose activity relation, Risk factor, Survival, Statistical model, Epidemiology, Human, Lung disease, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0394863
Code Inist : 002B30A01A1. Création : 25/01/1999.