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  1. Self-reported antiretroviral therapy in injection drug users.

    Article - En anglais

    Context. - The US Public Health Service and the International AIDS Society-USA recently published recommendations for antiretroviral therapy (ART) for persons infected with human immunodeficiency virus (HIV) ; however, anecdotal evidence suggests that HIV-infected injection drug users (IDUs) may not be receiving optimal care as defined by the recommendations.

    Objective

    - To assess ART use in HIV-infected IDUs.

    Design

    - A cross-sectional survey of self-reported ART use between July 1996 and June 1997 in IDUs.

    Setting

    - A community-based clinic affiliated with Johns Hopkins University, Baltimore, Md.

    Participants

    - A total of 404 HIV-infected IDUs with CD4+cell counts less than 0.50 x 109/L recruited into a longitudinal study in 1988 and 1989.

    Main Outcome Measure

    - Self-reported ART use was assessed : no current therapy, monotherapy, or combination therapy with or without a protease inhibitor.

    Results

    - One half (199/404 [49% ]) of patients reported no recent ART.

    A total of 14% (58/404) had monotherapy, 23% (90/404) were receiving combination therapy without a protease inhibitor, and 14% (57/404) had triple-combination therapy with a protease inhibitor.

    A multivariate analysis of factors associated with ART showed that care continuity and recent HIV-related outpatient visit (odds ratio [OR], 4.30 ; 95% confidence interval [CI], 2.36-7.81 and OR, 2.84 ; 95% CI, 1.66-4.88, respectively), CD4+cell count of less than 0.20x 109 (OR, 2.41 ; 95% CI, 1.51-3. (...)

    Mots-clés Pascal : Toxicomanie, SIDA, Virose, Infection, Chimiothérapie, Retroviridae, Virus, Comportement, Traitement, Efficacité traitement, Homme, Recommandation, Etats Unis, Amérique du Nord, Amérique, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : Drug addiction, AIDS, Viral disease, Infection, Chemotherapy, Retroviridae, Virus, Behavior, Treatment, Treatment efficiency, Human, Recommendation, United States, North America, America, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0394484

    Code Inist : 002B06D01. Création : 25/01/1999.