Context. - The use of systemic corticosteroids is a known risk factor for the development of cataracts.
- To determine whether treatment with inhaled corticosteroids is associated with cataract extraction in the elderly.
- Case-control study.
- Quebec universal health insurance program for all elderly (provincial health insurance plan database [RAMQ database]). Patients. - RAMQ enrollees 70 years and older.
The 3677 cases were patients with a cataract extraction between 1992 and 1994.
The 21 868 controls were randomly selected from patients who did not have a diagnosis of cataract and matched to cases on the index date of the case.
- Odds ratio of cataract extraction in patients with prolonged cumulative exposure to inhaled corticosteroids compared with nonusers.
- Excluding patients with systemic steroid treatment and after adjusting for age, sex, diabetes, systemic hypertension, glaucoma, ophthalmic steroids, and the number of physician claims for services, use of inhaled corticosteroids for more than 3 years was associated with undergoing cataract extraction (odds ratio [OR], 3.06 ; 95% confidence interval [CI], 1.53-6.13).
For high average daily doses of beclomethasone or budesonide (>1 mg), the OR was elevated after more than 2 years of treatment (OR, 3.40 ; 95% Cl, 1.49-7.76), whereas for low to medium doses (<=1 mg) of these drugs, the OR was 1.63 (95% CI, 0.85-3.13) after 2 years. (...)
Mots-clés Pascal : Corticostéroïde, Inhalation, Cataracte, Epidémiologie, Facteur risque, Toxicité, Médicament, Vieillard, Homme, Québec, Canada, Amérique du Nord, Amérique, Etude cas témoin, Oeil pathologie, Cristallin pathologie, Segment antérieur pathologie
Mots-clés Pascal anglais : Corticosteroid, Inhalation, Cataract, Epidemiology, Risk factor, Toxicity, Drug, Elderly, Human, Quebec, Canada, North America, America, Case control study, Eye disease, Lens disease, Anterior segment disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0394483
Code Inist : 002B02U09. Création : 25/01/1999.