Context. - Effective contraception is essential in women with prior gestational diabetes mellitus (GDM) but should not increase their already substantial risk of developing type 2 diabetes.
- To determine whether exposure to low-dose oral contraceptives increases the risk of developing type 2 diabetes mellitus in women with recent GDM.
- Retrospective cohort study of 904 Latinas with GDM who gave birth between January 1987 and March 1994, in whom postpartum diabetes was excluded at 4 to 16 weeks post partum.
- At their initial postpartum visit, 443 women selected a nonhormonal form of contraception, 383 received a low-dose, estrogen-progestin combination oral contraceptive (OC), and 78 breast-feeding women received the progestin-only OC.
When breast-feeding ended, patients initially taking progestin-only OCs were switched to combination OCs.
Patients were followed up periodically with oral glucose tolerance tests for up to 71/2 years.
- Person time was used to compute unadjusted average annual incidence rates of developing diabetes mellitus, as defined by the National Diabetes Data Group Criteria.
Survival analysis was used to compute the unadjusted cumulative incidence rates and adjusted relative risks of diabetes mellitus.
- The unadjusted average annual incidence rates of type 2 diabetes mellitus were 8.7%, 10.4%, and 26. (...)
Mots-clés Pascal : Diabète, Gestation, Contraception, Voie orale, Contraceptif, Dose faible, Epidémiologie, Facteur risque, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Endocrinopathie
Mots-clés Pascal anglais : Diabetes mellitus, Pregnancy, Contraception, Oral administration, Contraceptive, Low dose, Epidemiology, Risk factor, Human, Female, United States, North America, America, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0394470
Code Inist : 002B21E01A. Création : 25/01/1999.