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  1. Modelling the costs of paediatric HIV infection and AIDS : comparison of infected children born to screened and unscreened mothers.

    Article - En anglais

    Objective 

    To estimate the cost of managing children with HIV/AIDS in the UK from a health service perspective.

    Design and methods 

    Epidemiological, resource use and unit cost data were combined within a decision analytic model.

    A Markov model was developed to predict the prognoses of HIV-infected children under different assumptions about natural history, treatment efficacy and the timing of antiretroviral therapy.

    Resource use estimates for various stages of HIV/AIDS were based on published data relating to the UK health service and clinical judgement ; unit cost data were taken from a London centre.

    Results 

    The base-case results suggest that the cost of caring for an HIV-infected child is higher if the mother's infection was known about at or before the child's birth (antenatal screened cohort) : lifetime costs ranged from £46 427 to £119 502 per child in the screened cohort and from £38 691 to £86 014 in the unscreened cohort.

    However, the screened cohort benefited from longer life expectancy (base-case, 11.66 versus 10.09 years) and AIDS-free life expectancy (base-case, 7.13 years versus 6.22 years).

    Results are sensitive to assumptions about natural history and treatment efficacy : for example, if antiretroviral therapy was initiated at birth, and assuming optimistic natural history parameters, discounted costs could increase to £215 077 and the additional lifetime cost of a child born to a screened mother could be £72 491. (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Enfant, Homme, Modélisation, Coût, Dépistage, Prénatal, Etude comparative, Traitement, Chimiothérapie, Soin, Estimation, Immunopathologie, Immunodéficit, Economie santé

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Child, Human, Modeling, Costs, Medical screening, Prenatal, Comparative study, Treatment, Chemotherapy, Care, Estimation, Immunopathology, Immune deficiency, Health economy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0393691

    Code Inist : 002B05C02D. Création : 25/01/1999.