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  1. Nocturnal excretion of a urinary melatonin metabolite among electric utility workers.

    Article - En anglais

    Objectives The effects of 60-Hz magnetic field and ambient light exposures on the pineal hormone melatonin were studied among electric utility workers.

    Methods Personal exposure was measured at 15-second intervals over 3 consecutive 24-hour periods.

    Exposure metrics based on magnetic field intensity, intermittence, or temporal stability were calculated for periods of work, home, and sleep.

    A rate-of-change metric (RCM) was used to estimate intermittence, and the standardized RCM (RCMS=RCM/standard deviation) was used to evaluate temporal stability.

    The effects of magnetic field exposure on total overnight 6-hydroxymelatonin sulfate (6-OHMS) excretion and creatinine-adjusted nocturnal 6-OHMS (6-OHMS/cr) concentration were analyzed with adjustment for age, month, and light exposure.

    Results Magnetic field intensity, intermittence, or cumulative exposure had little influence on nocturnal 6-OHMS excretion.

    Residential RCMS magnetic field exposures were associated with lower nocturnal 6-OHMS/cr concentrations.

    In multivariate statistical analyses, the interaction term for geometric mean and RCMS magnetic field exposures at home was associated with lower nocturnal 6-OHMS/cr and overnight 6-OHMS levels.

    Modest reductions in the mean 6-OHMS levels occurred after RCMS exposures during work. (...)

    Mots-clés Pascal : Compagnie électricité, Champ magnétique, Toxicité, Chronobiologie, Eclairage, Homme, Exposition professionnelle, Médecine travail, Mélatonine, Epiphyse, Rythme circadien, Rythme biologique

    Mots-clés Pascal anglais : Electric utility, Magnetic field, Toxicity, Chronobiology, Lighting, Human, Occupational exposure, Occupational medicine, Melatonin, Pineal body, Circadian rhythm, Biological rhythm

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0393528

    Code Inist : 002A08E. Création : 25/01/1999.