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  1. Costs and benefits of respiratory syncytial virus immunoglobulin to prevent hospitalization for lower respiratory tract illness in very low birth weight infants.

    Article - En anglais

    Background

    Respiratory syncytial virus immunoglobulin intravenous (RSV-IGIV) has been shown to reduce the risk of lower respiratory illness (LRI) hospitalization in preterm infants and infants with bronchopulmonary dysplasia (BPD).

    The purpose of this analysis was to estimate the economic costs and benefits of prophylaxis with RSV-IGIV in these groups.

    Methods

    The analysis was performed from a payer's perspective and therefore included only costs and cost savings that would be realized by an insurer.

    Estimates of the direct costs of prophylaxis and the risk and cost of LRI hospitalization were based on data about preterm very low birth weight infants cared for at our medical center.

    Estimates of the reduction in risk of LRI hospitalization associated with RSV-IGIV were based on data from a randomized trial (the PREVENT Study).

    Results

    The range of cost for a five-dose course of RSV-IGIV was estimated to be $3280 to $8800 for infants weighing 1.2 to 10.0 kg at the time of the initial dose.

    Risks of LRI hospitalization were estimated to be 12,17 and 28%, respectively, for preterm infants without BPD, with mild BPD and with moderate to severe BPD.

    Estimates of duration and per diem cost of LRI hospitalizations were, respectively, 5 days and $971.

    The estimated net cost of prophylaxis per infant ranged between $5415 for a 6-kg infant without BPD to $1689 for an infant with BPD and age<3 months. (...)

    Mots-clés Pascal : Poids naissance très faible, Virus respiratoire syncytial humain, Pneumovirus, Pneumovirinae, Paramyxoviridae, Mononegavirales, Virus, Virose, Infection, Voie respiratoire, Immunoprophylaxie, Prévention, Immunoglobuline, Voie intraveineuse, Hospitalisation, Nourrisson, Homme, Coût, Estimation, Bénéfice, Prématuré, Gestation pathologie, Nouveau né pathologie, Economie santé

    Mots-clés Pascal anglais : Very low birthweight, Human respiratory syncytial virus, Pneumovirus, Pneumovirinae, Paramyxoviridae, Mononegavirales, Virus, Viral disease, Infection, Respiratory tract, Immunoprophylaxis, Prevention, Immunoglobulins, Intravenous administration, Hospitalization, Infant, Human, Costs, Estimation, Profit, Premature, Pregnancy disorders, Newborn diseases, Health economy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0392524

    Code Inist : 002B05C02B. Création : 25/01/1999.