Etiology and risk factors of 180 cases of native valve endocarditis report from a 5-year national prospective survey in Slovak Republic.
Risk factors, etiology, and outcome of 180 cases of infective endocarditis (IE) in the Slovak Republic for 5 years were prospectively studied in a national survey.
According to the Duke Endocarditis Service Criteria (1994), 169 cases were considered definitive and 21 possible/probable.
The aortic value was infected in 46.7%, mitral in 47.2%, and tricuspidal/pulmonary in 6.1% of cases.
The majority of endocarditis cases was caused by Staphylococcus aureus and coagulase-negative staphylococci (CNS) (33.3%) ; only 12.2% were due to viridans streptococci ; 11.7% were due to Enterococcus faecalis ; 6.1%, due to Haemophilus spp. ; 10.1% due to other organisms ; and 26.7% were culture negative.
Single positive cultures of CNS were not considered clinically significant.
More than 25% of 180 patients were older than 60 years.
Rheumatic fewer was a risk factor in 35.5%, dental surgery in 20.5%, prior cardiovascular in 7.8%, and neoplasia in 6.7%. All patients were treated with antimicrobials (average length of therapy was 29.5 days) and 33.3%, of patients also had surgery (valvular prosthesis replacement).
Forty (22.2%) died, and 140 (77.8%) survived at day 60 after the diagnosis of endocarditis was made.
All 40 deaths were attributable to infection.
Univariate analysis comparing deaths and survivors did not show significant differences in most of the recorded risk factors between both groups, except age>60 (40.0% versus 21.4%, p<0.05), Staphylococcal etiology (...)
Mots-clés Pascal : Facteur risque, Etiologie, Infection nosocomiale, Surveillance, Epidémiologie, Endocardite, Infection, Appareil circulatoire pathologie, Cardiopathie, Endocarde pathologie, Homme, Slovaquie, Europe
Mots-clés Pascal anglais : Risk factor, Etiology, Nosocomial infection, Surveillance, Epidemiology, Endocarditis, Infection, Cardiovascular disease, Heart disease, Endocardial disease, Human, Slovakia, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0391481
Code Inist : 002B30A01A2. Création : 25/01/1999.