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  1. Epidemiologic and genetic studies of dementia of the Alzheimer type in Japan.

    Article - En anglais

    We carried out two separate epidemiological studies on long-term changes. 10 years apart, on the prevalence rate of dementia in the elderly by the same method for the same area in Japan.

    We also performed a genetic study of patients with dementia of the Alzheimer type (DAT) based on the epidemiological studies.

    The number of patients with dementia was much larger in 1990 than in 1980.

    Especially, the number of mildly demented patients was significantly larger in 1990 than in 1980.

    The 35 patients with DAT did not show any mutations of amyloid-bêta protein precursor, presenilin I and presenilin 2 genes.

    The frequency of apolipoprotein E (apo E) epsilon4 allele in DAT was significantly higher than that in control subjects (p<0.005).

    This study suggests that the frequency of DAT may increase by aging of the population in the future and we confirm the close association between apoE epsilon4 allele and DAT in a community-based study in Japan.

    Mots-clés Pascal : Démence Alzheimer, Japon, Asie, Long terme, Mutation, Protéine précurseur amyloïde, Préséniline, Génotype, Allèle, Apolipoprotéine E, Epidémiologie, Prévalence, Déterminisme génétique, Adulte, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative

    Mots-clés Pascal anglais : Alzheimer disease, Japan, Asia, Long term, Mutation, Amyloid precursor protein, Presenilin, Genotype, Allele, Apolipoprotein E, Epidemiology, Prevalence, Genetic determinism, Adult, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0387493

    Code Inist : 002B17G. Création : 25/01/1999.