Risk of pulmonary tuberculosis relative to silicosis and exposure to silica dust in South African gold miners.
Objectives-To investigate the following questions. (1) Is silica dust on its own, without the presence of silicosis, associated with an increased risk of pulmonary tuberculosis (PTB) in workers exposed to silica dust ? (2) In the absence of silicosis is the excess risk dose related ? (3) What is the predominant chronological sequence between the development of PTB and the development of silicosis after the end of exposure to dust ?
Methods-A cohort of 2255 white South African gold miners has been followed up from 1968 to 1971, when they were 45-55 years of age, to 31 December 1995 for the incidence of PTB.
During the follow up 1592 (71%) men died.
Of these, 1296 (81%) had a necropsy done at the National Centre for Occupational Health (NCOH) to determine the presence of silicosis and PTB.
The incidence of PTB in the cohort was studied relative to cumulative exposure to dust and the onset of silicosis.
For the miners with necropsy, the incidence for PTB was studied relative to the severity of silicosis found at necropsy.
There were 115 subjects who developed PTB.
The total person-years of follow up was 39 319.
For the whole cohort, the factors associated with increased risk of PTB were cumulative exposure to dust (mg/m3. y) (the adjusted rate ratio (RR) 1.07 ; (95% confidence interval (95% CI) 1.04 to 1.10)), silicosis diagnosed radiologically (3.96 (2.59 to 6.06)), and tobacco pack-years (1.02 (1.01 to 1.03)). (...)
Mots-clés Pascal : Silice, Poussière, Or, Mine, Industrie extractive, Tuberculose, Mycobactériose, Bactériose, Infection, Poumon, Facteur risque, Homme, Exposition professionnelle, Médecine travail, République Sud Africaine, Afrique, Epidémiologie, Silicose, Appareil respiratoire pathologie, Poumon pathologie, Toxicité, Association morbide
Mots-clés Pascal anglais : Silica, Dust, Gold, Mine, Mining industry, Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Lung, Risk factor, Human, Occupational exposure, Occupational medicine, South Africa, Africa, Epidemiology, Silicosis, Respiratory disease, Lung disease, Toxicity, Concomitant disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0387350
Code Inist : 002B03L03. Création : 25/01/1999.