Objectives-The primary study aim was to examine the possible role of cadmium as a risk factor for osteoporosis by determining the bone mineral density (BMD) in workers previously exposed to cadmium.
A second objective was to validate the BMD data obtained with a movable instrument.
Methods-43 workers who were exposed to cadmium for <=5 years before 1978 were studied.
Cadmium in blood (B-Cd) and urine (U-Cd) were used as dose estimates.
The BMD was assessed in the forearm, the spine, and the hip (neck and trochanter) with a dual energy x ray absorptiometry (DXA) instrument.
Age and sex matched reference populations were used to compute Z scores, commonly used to assess osteoporosis.
The mean forearm Z score was - 0.60 (95% confidence interval (95% CI) - 1.08 to - 0.12) in the group exposed to cadmium.
The mean Z score for the spine was - 0.47 (95% CI - 0.92 to - 0.03), for the hip neck - 0.40 (95% CI - 0.75 to - 0.05), and for the hip trochanter - 0.22 (95% CI - 0.52 to - 0.07).
The decrease in forearm BMD was correlated with age (p=0.002) and B-Cd (p=0.040).
No such correlations were found for the other sites.
Workers with tubular proteinuria had a lower forearm BMD (p=0.029) and a lower Z score (p=0.072) than workers without tubular proteinuria.
Conclusions-There was a suggested dose-effect relation between cadmium dose and bone mineral density.
Furthermore, there was a dose-response relation between cadmium dose and osteoporosis. (...)
Mots-clés Pascal : Cadmium, Métal lourd, Toxicité, Ostéoporose, Facteur risque, Homme, Exposition professionnelle, Médecine travail, Densité, Os, Système ostéoarticulaire pathologie, Ostéopathie
Mots-clés Pascal anglais : Cadmium, Heavy metal, Toxicity, Osteoporosis, Risk factor, Human, Occupational exposure, Occupational medicine, Density, Bone, Diseases of the osteoarticular system, Bone disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0386741
Code Inist : 002B03L05. Création : 25/01/1999.