Clinical outcome of hepatitis C as a function of mode of transmission.
Several reports suggest that posttransfusion hepatitis C causes more aggressive histological activity than disease that is acquired via other routes.
We sought to determine whether mode of transmission affects disease outcome.
We studied the demographics, presenting laboratory data, and clinical course of 627 consecutively evaluated nonalcoholic patients with chronic hepatitis C. Two hundred eighty-two patients (45%) were transfusion recipients, 262 (42%) acquired the disease via other routes of percutaneous exposure, and 83 (13%) were without risks.
Liver histology was available in 463 patients (215 transfusion recipients, 195 non-transfusion recipients, and 53 who were were without risks) and showed noncirrhosis in 274 (59%), cirrhosis in 173 (37%), and hepatocellular carcinoma in 16 patients (4%) who also had underlying cirrhosis.
Duration of follow-up was 1 to 25 years (mean, 48 months ; median, 21 years).
One hundred eighteen of 173 (68%) cirrhotic patients were transfusion recipients ; 40 of 173 (23%) cirrhotic patients acquired infection via other percutaneous exposure, and the remainder were without known risk factors (P<. 001).
Among the 215 patients with blood transfusions for whom histology was available, 118 of 215 (55%) had cirrhosis and 89 of 215 (41%) were noncirrhotic (P<. 001) ; 8 transfused patients (4%) had hepatocellular carcinoma. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Effet biologique, Mode transmission, Contamination, Transfusion, Indice gravité, Agressivité, Evolution, Survie, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Biological effect, Transmission mode, Contamination, Transfusion, Severity score, Aggressiveness, Evolution, Survival, Epidemiology, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0386657
Code Inist : 002B05C02G. Création : 25/01/1999.