Measurement of vitamin D3 metabolites in smelter workers exposed to lead and cadmium.
Objectives-To investigate the effects of lead and cadmium on the metabolic pathway of vitamin D3.
Methods-Blood and urinary cadmium and urinary total proteins were measured in 59 smelter workers occupationally exposed to lead and cadmium.
In 19 of these workers, the plasma vitamin D3 metabolites, (25. - hydroxycholecalciferol (25 OHD3), 24R, 25-dihydroxycholecalciferol (24R, 25 (OH) 2D3) and 1alpha, 25-dihydroxycholecalciferol (1alpha, 25 (OH) 2D3)) were measured together with blood lead.
Vitamin D3 metabolites were measured by radioimmunoassay, (RIA), lead and cadmium by atomic absorption spectrophotometry, and total proteins with a test kit.
Ranges for plasma 25 (OH) D3,24R, 25 (OH) 2D3 and 1alpha, 25 (OH) 2D3 were 1.0-51.9 ng/ml, 0.6-5.8 ng/ml, and 0.1-75.7 pg/ml, respectively.
Ranges for blood lead were 1-3.7 mumol/l, (21-76 mug/dl), blood cadmium 6-145 nmol/l, and urinary cadmium 3-161 nmol/l. Total proteins in random urine samples were 2.1-32.6 mg/dl.
Concentrations of lead and cadmium in blood showed no correlation (correlation coefficient - 0.265) but there was a highly significant correlation between blood and urinary cadmium.
Concentrations for 24R, 25 (OH) 2D3 were depressed below the normal range as blood and urinary cadmium increased, irrespective of lead concentrations.
High cadmium concentrations were associated with decreased plasma 1alpha, 25 (OH) 2D3 when lead concentrations were<1. (...)
Mots-clés Pascal : Métal lourd, Plomb, Cadmium, Toxicité, Fonderie, Industrie métallurgique, Exposition professionnelle, Médecine travail, Cholécalciférol, Vitamine, Surveillance biologique, Marqueur biologique, Sang, Liquide biologique, Homme
Mots-clés Pascal anglais : Heavy metal, Lead, Cadmium, Toxicity, Foundry, Metallurgical industry, Occupational exposure, Occupational medicine, Colecalciferol, Vitamin, Biological monitoring, Biological marker, Blood, Biological fluid, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0386367
Code Inist : 002B03L05. Création : 25/01/1999.