Immunologic response to tetanus toxoid in the elderly : One-year follow-up.
Society for Academic Emergency Medicine Annual Meeting. Washington, DC, USA, 1997/05/22.
To determine whether elderly patients documented to have nonprotective titers of anti-tetanus antibodies (ATA) are able to achieve and maintain protective ATA titers for at least 1 year after tetanus immunization.
Thirty-five outpatients aged 65 or older with documented inadequate ATA titers were given 1 tetanus immunization.
Repeat titers were obtained 2 months and 12 months after immunization.
Titers were measured with an enzyme-linked immunoassay kit (Bindazyme kit).
ATA titers in excess of. 17 IU were considered protective.
The study was conducted at a large urban geriatric center.
The mean age of participants was 78.7 years ; 86% (24/28) were women.
Repeat ATA titers were obtained an average of 122 days and 493 days after immunization.
The mean preimmunization ATA titer was. 1 IU, (range. 04 to. 16 IU).
After immunization, the 2-month ATA titer rose a mean of. 61 (95% confidence interval [Cl]. 35 to. 87) IU, with 86% (30/35) achieving protective titers.
After 1 year only 28 of 35 patients were available for follow-up.
Protective titers had been present in all 7 patients lost to follow-up.
After 1 year, 82% (23/28) patients had protective titers.
The mean ATA titer for the 28 patients was. 54 (95% Cl - 78 to 1.86) IU, a significant increase from preimmunization levels (P=002).
However, ATA titers changed - 18 (95% Cl - 98 to. 62) IU between 2 months and 1 year (P=02). (...)
Mots-clés Pascal : Tétanos, Bactériose, Infection, Immunisation, Anticorps, Vaccination, Prévention, Réponse immune, Taux, Vieillard, Homme, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Tetanus, Bacteriosis, Infection, Immunization, Antibody, Vaccination, Prevention, Immune response, Rate, Elderly, Human, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0382184
Code Inist : 002B05B02P. Création : 25/01/1999.