Influence of heavy metals, especially lead, on lipid metabolism, serum alpha-tocopherol level, total antioxidant status, and erythrocyte redox status of copper smelter workers.
International Hans Wolfgang Nürnberg Memorial Symposium on "Metal Compounds in Environment and Life". Modena, ITA, 1997/06/04.
An assessment of influence of the occupational exposure to heavy metals, especially lead, on serum lipids (including lipid peroxides), total antioxidant status, erythrocyte redox status, and serum alpha-tocopherol level was performed in a group of 141 healthy male copper smelter workers.
The following parameters were measured :
Blood lead and cadmium levels. serum manganese, copper, zinc, calcium and magnesium levels, free erythrocyte protoporphyrins (FEP), total cholesterol, HDL2-HDL3-cholesterol, triglycerides and lipid peroxides in serum, erythrocyte superoxide dismutase (SODE), catalase (CatE) and glutathion peroxidase (PxGSHE) activities, erythrocyte reduced glutathione level (GSHE), serum alpha-tocopherol level, and serum total antioxidant status (TAS).
Mean PbB was within the norm range (328.2 ± 141.7 mug/L), but mean Mns concentration slightly exceeded 10 mug/L (11.04 ± 3.79 mug/L).
Mean cholesterol and triglycerides concentrations were near the highest borderline values.
We found a significantly negative correlation between lead levels and HDL3-cholesterol (r=0.253.
Erythocyte catalase activity and TAS were lowered.
TAS showed significant negative correlation with PbB.
A group of workers with PbB= 400 mug/L had significantly lower CatE, lower TAS, and lower HDL3-cholesterol, compared to the workers with Pb<400 mug/L. We have also found positive correlation between alpha-tocopherol and total cholesterol (r=0.267, P<0. (...)
Mots-clés Pascal : Métal lourd, Plomb, Toxicité, Lipide, Sérum, alpha-Tocophérol, Vitamine, Erythrocyte, Potentiel oxydoréduction, Antioxydant, Fonderie, Industrie métallurgique, Homme, Exposition professionnelle, Médecine travail
Mots-clés Pascal anglais : Heavy metals, Lead, Toxicity, Lipids, Serum, alpha-Tocopherol, Vitamins, Red blood cell, Redox potential, Antioxidants, Foundry practice, Metallurgical industry, Human, Occupational exposure, Occupational medicine
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0381616
Code Inist : 002B03L05. Création : 25/01/1999.