An international program of surveillance of bloodstream infections (BSIS) in the United States, Canada, and South America between January and December 1997 detected 306 episodes of candidemia in 34 medical centers (22 in the United States, 6 in Canada, and 6 in South America).
Eighty percent of the BSIs were nosocomial and 50% occurred in patients hospitalized in an intensive care unit.
Overall, 53.3% of the BSIs were due to Candida albicans, 15.7% were due to C. parapsilosis, 15.0% were due to C. glabrata, 7.8% were due to C. tropicalis, 2.0% were due to C. krusei, 0.7% were due to C. guilliermondii, and 5.8% were due to Candida spp.
However, the distribution of species varied markedly by country.
In the United States, 43.8% of BSIs were due to non-C. albicans species.
C. glabrata was the most common non-C. albicans species in the United States.
The proportion of non-C. albicans BSIs was slightly higher in Canada (47.5%), where C. parapsilosis, not C. glabrata, was the most common non-C. albicans species.
C. albicans accounted for 40.5% of all BSIs in South America, followed by C. parapsilosis (38.1%) and C. tropicalis (11.9%). Only one BSI due to C. glabrata was observed in South American hospitals.
Among the different species of Candida, resistance to fluconazole (MIC, =64 mug/ml) and itraconazole (MIC, =1.0 mug/ml) was observed with C. glabrata and C. krusei and was observed more rarely among other species.
Isolates of C. albicans, C. parapsilosis, C. (...)
Mots-clés Pascal : Candida, Fungi Imperfecti, Fungi, Thallophyta, Epidémiologie, Résistance, Antifongique, Fongémie, Mycose, Infection, Candidose, Surveillance sanitaire, Coopération internationale, Programme sanitaire, Prévalence, Répartition géographique, Etats Unis, Amérique du Nord, Amérique, Amérique du Sud, Canada, Levure, Programme SENTRY
Mots-clés Pascal anglais : Candida, Fungi Imperfecti, Fungi, Thallophyta, Epidemiology, Resistance, Antifungal agent, Fungemia, Mycosis, Infection, Candidiasis, Sanitary surveillance, International cooperation, Sanitary program, Prevalence, Geographic distribution, United States, North America, America, South America, Canada, Yeast
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0380693
Code Inist : 002A05D05. Création : 25/01/1999.