Sera from 450 individuals between the age of I and 80 years, representing the general population of the Czech Republic, were tested for the presence of antibodies to human-papillomavirus (HPV) - derived antigens.
The following antigens were used :
(i) HPVI virions ;
18 and - 33-virus-like particles (VLP) ;
(iii) peptides derived from L2 open reading frames (ORFs) of HPV16 and HPV6/11 ;
(iv) peptides derived from HPV16 E2,
E4 and E7 ORFs of HPV16.
The prevalence of antibodies reactive with the capsid-derived antigens was age-dependent, while no clear age dependence was observed in the distribution of antibodies to peptides derived from HPV16 early proteins.
In individual sera, high correlations between the presence of antibodies reactive with the 2 L2 peptides, also between the antibodies reactive with different VLPs, were found.
While the simultaneous presence of the 2 L2 antibodies was frequently detected in individual sera in all age groups, the simultaneous occurrence of VLP antibodies was detected mostly in subjects older than 20 years.
There were no significant differences in HPV-antibody distribution between men and women.
Mots-clés Pascal : Virose, Infection, Papillomavirus humain 1, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Papillomavirus humain 16, Papillomavirus humain 18, Prévalence, Sérologie, Epidémiologie, République tchèque, Europe, Homme
Mots-clés Pascal anglais : Viral disease, Infection, Human papillomavirus 1, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Human papillomavirus 16, Human papillomavirus 18, Prevalence, Serology, Epidemiology, Czech Republic, Europe, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0374794
Code Inist : 002B05A02. Création : 25/01/1999.