We prospectively studied the gender differences of baseline variables, therapies, and outcomes among a cohort of 369 Chinese patients with acute myocardial infarction from 1990 to 1995.
There were 277 male and 92 female patients.
The male gender had a younger mean (±SD) age (61.5±10.7 vs. 67.1±11.7 years, P<0.0001).
Hypercholesterolemia (201.2±44.2 vs. 187.5±43.7 mg/dl.
P=0.0111) and obesity (25.0 vs. 15.9%, P=0.0494) were more prominent in the female.
Smoking was more prevalent in the male (78.3 vs. 18.5%, P<0.0001).
The male group also had more frequent use of thrombolytic agents (19.1 vs. 9.8%, P=0.0377), bêta-blockers (61.7 vs. 47.8%, P=0.0191) and heparin (25.3 vs. 12.0%, P=0.0075) ; but less use of angiotensin-converting enzyme inhibitors (6.9 vs. 15.2%, P=0.0149).
The condition on admission was worse in the female group (Killip classification (1.5±0.9 vs. 1.9±1.0, P=0.0022), myocardial failure (8.7 vs. 2.9%, P=0.0178) and cardiomegaly (65.2 vs. 53.1%, P=0.0419).
During a follow-up duration of 26.4±24.1 and 22.9±23.9 months respectively, the mortality rate was lower in the male (19.5 VS, 30.4%, P=0.0288).
However after adjustment for the effect of age, thc differences in Killip classification, myocardial failure, cardiomegaly and mortality became insignificant.
Mots-clés Pascal : Infarctus, Myocarde, Chine, Asie, Homme, Femelle, Mâle, Sexe, Traitement, Evolution, Facteur risque, Chimiothérapie, Pronostic, Etude comparative, Epidémiologie, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Infarct, Myocardium, China, Asia, Human, Female, Male, Sex, Treatment, Evolution, Risk factor, Chemotherapy, Prognosis, Comparative study, Epidemiology, Cardiovascular disease, Coronary heart disease, Myocardial disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0374757
Code Inist : 002B12A03. Création : 25/01/1999.