Risk of lung cancer associated with residential radon exposure in south-west England : a case-control study.
Studies of underground miners occupationally exposed to radon have consistently demonstrated an increased risk of lung cancer in both smokers and non-smokers.
Radon exposure also occurs elsewhere, especially in houses, and estimates based on the findings for miners suggest that residential radon is responsible for about one in 20 lung cancers in the UK, most being caused in combination with smoking.
These calculations depend, however, on several assumptions and more direct evidence on the magnitude of the risk is needed.
To obtain such evidence, a case-control study was carried out in south-west England in which 982 subjects with lung cancer and 3185 control subjects were interviewed.
In addition, radon concentrations were measured at the addresses at which subjects had lived during the 30-year period ending 5 years before the interview.
Lung cancer risk was examined in relation to residential radon concentration after taking into account the length of time that subjects had lived at each address and adjusting for age, sex, smoking status, county of residence and social class.
The relative risk of lung cancer increased by 0.08 (95% Cl - 0.03,0.20) per 100 Bq m-3 increase in the observed time-weighted residential radon concentration.
When the analysis was restricted to the 484 subjects with lung cancer and the 1637 control subjects with radon measurements available for the entire 30-year period of interest, the corresponding increase was somewhat higher (...)
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Facteur risque, Exposition, Radon, Radioisotope, Zone résidentielle, Sud ouest, Angleterre, Grande Bretagne, Royaume Uni, Europe, Epidémiologie, Erreur mesure, Etude cas témoin, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Risk factor, Exposure, Radon, Radioisotope, Residential zone, Southwest, England, Great Britain, United Kingdom, Europe, Epidemiology, Measurement error, Case control study, Human, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0372554
Code Inist : 002B11A. Création : 25/01/1999.