logo BDSP

Base documentaire

  1. Mutual antagonism of rheumatoid arthritis and hay fever ; a role for type 1/type 2 T cell balance.

    Article - En anglais

    Objectives-The balance between interferon gamma (IFNgamma) and interleukin 4 (IL4) producing T cells (T1 and T2 cells) seems to be of importance in many (auto) immune disorders.

    In general, T1 cell activity is important in cellular immunity whereas T2 cell activity plays a part in humoral responses.

    T1 cell activity predominates in joints of patients with rheumatoid arthritis (RA) whereas T2 cell activity is characteristic of atopic syndromes.

    This study investigated whether the prevalence of hay fever in RA is low and if severity of RA (T1 cell activity) can be influenced by the concomitant occurrence of a T2 cell mediated disease (hay fever).

    Methods-The prevalence of hay fever was assessed in 643 consecutive (RA and non-RA) patients seen in our outpatient clinic and confirmed by skin test and specific IgE.

    Of this group the 12 RA patients with hay fever were compared with RA patients without hay fever (matched for age, sex, and disease duration).


    The prevalence of hay fever in RA patients is lower than in non-RA patients (4% versus 8%), and yields a relative risk for RA patients to develop hay fever of 0.48.

    RA patients with hay fever showed a lower disease activity (erythrocyte sedimentation rate, C reactive proten, Thompson joint score, and radiographic joint damage (Sharp) score) than RA patients without hay fever. (...)

    Mots-clés Pascal : Polyarthrite rhumatoïde, Homme, Association, Asthme, Allergie, Exploration, Lymphocyte, Réponse immune, Immunité cellulaire, Epidémiologie, Prévalence, Symptomatologie, Chronique, Allergène, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Rhume des foins, Lymphocyte Th1, Lymphocyte Th2

    Mots-clés Pascal anglais : Rheumatoid arthritis, Human, Association, Asthma, Allergy, Exploration, Lymphocyte, Immune response, Cellular immunity, Epidemiology, Prevalence, Symptomatology, Chronic, Allergen, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Respiratory disease, Obstructive pulmonary disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0370786

    Code Inist : 002B15D. Création : 25/01/1999.