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  1. Effects of central nervous system polypharmacy on falls liability in community-dwelling elderly.

    Article - En anglais


    While central nervous system (CNS) active medications such as psychotropics and narcotic analgesics have been implicated in contributing to falls in older adults, the combined effect of multiple CNS-active medications has not been investigated.

    The purpose of this study was to examine the influence, in community-dwelling elderly, of (1) taking multiple CNS-active medications on fall liability and (2) individual classes of CNS-active medications (using discrete drug classification) on the risk of falls after controlling for important confounders - age, mobility, cognition and depression.


    305 community-dwelling male veterans (age : 70-104) were screened at study entry for mobility, cognition and depression.

    CNS-active medications were categorized as benzodiazepines, other sedative-hypnotics, neuroleptics, tricyclic antidepressants, and opioid analgesics.

    Subjects were prospectively followed for 6 months to monitor falls ; at the end of this time period, subjects were classified as fallers (at least one fall) or nonfallers.

    The relationship between CNS-active drug use and falls was examined using multivariable analyses.


    The risk of falls was significantly greater in CNS-active medication users as compared with nonusers.

    Adjusted odds ratio for one CNS-active drug was 1.54 (95% confidence interval 1.07-2.22) and for two or more agents 2.37 (95% confidence interval 1.14-4.94). (...)

    Mots-clés Pascal : Chute, Traumatisme, Facteur risque, Toxicité, Association médicamenteuse, Psychotrope, Système nerveux central, Vieillard, Homme, Etablissement troisième âge

    Mots-clés Pascal anglais : Fall, Trauma, Risk factor, Toxicity, Drug combination, Psychotropic, Central nervous system, Elderly, Human, Homes for the aged

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0368211

    Code Inist : 002B02U10. Création : 25/01/1999.